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Effect of hyperthermia on rat fetus palate epithelium

A D Toneto1, R A Lopes, P T Oliveira

  • 1Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Brasil.

Brazilian Dental Journal
|January 1, 1994
PubMed

Maternal hyperthermia during gestation induces delayed cellular growth and differentiation in fetal rat palate epithelium, with increased nuclear, cytoplasmic and cellular volumes, increased epithelial thickness, decreased keratin and cellular numerical density.

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...