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Related Experiment Videos

[Benign prostatic hyperplasia--its treatment with Proscar]

P Panchev, K Neĭkov, P Simeonov

    Khirurgiia
    |January 1, 1996
    PubMed
    Summary

    Proscar effectively treats benign prostate hyperplasia in older men. This 5-alpha reductase inhibitor improved urinary symptoms and prostate volume in most patients within six months.

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    Area of Science:

    • Urology
    • Pharmacology
    • Andrology

    Context:

    • Benign prostate hyperplasia (BPH) is a common condition in aging men, often requiring medical or surgical intervention.
    • Current treatments for BPH include conservative management and surgical procedures.
    • Proscar (finasteride) is a synthetic 4-azosteroid and a specific inhibitor of 5-alpha reductase.

    Purpose:

    • To evaluate the efficacy of Proscar (finasteride) in treating benign prostate hyperplasia.
    • To assess the impact of Proscar on prostate gland volume, residual urine, and maximal urinary flow.
    • To determine the response rate to Proscar treatment in patients with BPH, including those with complete urinary retention.

    Summary:

    • A study involving 35 male patients with benign prostate hyperplasia treated with Proscar 5 mg daily for six months.
    • The treatment demonstrated significant improvements in prostate gland volume, residual urine, and maximal urinary flow.
    • Overall, 71.44% of patients showed a complete response, 22.85% had a partial response, and 5.71% showed no improvement.

    Impact:

    • Proscar offers a promising therapeutic option for managing benign prostate hyperplasia.
    • The drug's ability to stabilize testosterone and dihydrotestosterone (DHT) levels contributes to its effectiveness.
    • These findings support the use of Proscar as a conservative treatment for BPH, potentially reducing the need for surgery.

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