[The action of ACTH 4-10 on the behavior of mice from different inbred strains]

We found that the administration of ACTH4-10 fragment to newborn mice of several strains (DBA/2, CBA, C57BL/6J, CBARb, and BLRb) for 5 days from the second day of life led to changes of several behavioral characteristics of adult animals. The effect of peptide administration on exploratory behavior of mice and on following the direction of stimulus movement are opposite to those induced by pain stimulation, i.e., administration of a solvent. The results are interpreted as a possible antistress effect of the peptide, which is realized during the period of neurodifferentiation. These data are discussed in terms of a possible effect of the used peptide on differentiation of the nervous system.