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[A new type of ionotropic glutamate receptors]
M M Solov'ev1, E A Barnard, E V Grishin
1Department of Molecular Neurobiology, Medical School, Royal Free Hospital, London, Great Britain.
Abstract:
The possibility of the existence of a new type of ionotropic glutamate receptor differing from NMDA and non-NMDA receptors was confirmed by cloning cDNA for XenNR1, a channel-forming subunit of the glutamate receptor from the Xenopus laevis brain. Cotransfection of the HEK-293 cells with the cDNAs for XenNR1 and XenU1 (a non-NMDA receptor subunit from X. laevis brain) resulted in the biosynthesis of a functionally active heterosubunit receptor composed of NMDA and non-NMDA subunits. The functional co-expression of the XenNR1 and XenU1 cDNAs is the first direct evidence for the existence of a new type of glutamate receptor.