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Postoperative adjuvant locoregional chemotherapy in patients with hepatocellular carcinoma
R Izumi1, K Shimizu, I Miyazaki
1Department of Surgery, Toyama City Hospital.
Background/Aims:
Hepatocellular carcinoma (HCC) recur frequently in HCC patients with invasive factors such as vascular invasion and intrahepatic metastasis and its prevention is important in obtaining better surgical survival.
Material And Methods:
Palliative resection with locoregional therapy for multinodular HCC was performed to prevent postoperative complications in patients with poor hepatic reserve. Disease-free survival (DFS) and survival for these patients who underwent hepatic resection for noninvasive HCC, and for invasive HCC with or without adjuvant chemotherapy were analyzed to determine the effects of adjuvant chemotherapy. Survival of palliative resection for HCC was analyzed to determine the effect of reduction surgery.
Results:
DFS and survival of patients with adjuvant chemotherapy was better than those of patients without adjuvant chemotherapy, but not significantly (DFS; p = 0.0508, survival; p = 0.0570), and the survival of patients without adjuvant chemotherapy was almost equal to that of patients who underwent palliative resection. Adjuvant chemotherapy was effective in improving survival, but the effect was not satisfactory.
Conclusions:
Palliative resection was effective in treating multinodular HCC. Further trials are required to improve the surgical survival of patients with HCC.