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Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus.

Human genetics·1997

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[Effects of alcohol on urate metabolism].

Nihon rinsho. Japanese journal of clinical medicine·1997

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[A case report of renal cell carcinoma with bilateral adrenal metastases].

Hinyokika kiyo. Acta urologica Japonica·1997

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An asymptomatic germline missense base substitution in the hypoxanthine phosphoribosyltransferase (HPRT) gene that reduces the amount of enzyme in humans.

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Generation and molecular characterisation of monoclonal IgG4 rheumatoid factor from a patient with rheumatoid arthritis.

Annals of the rheumatic diseases·1997

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[Alcohol ingestion and hyperuricemia].

Nihon rinsho. Japanese journal of clinical medicine·1996

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Related Experiment Video

Updated: Jul 13, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

[How to select and use urate lowering agents for hyperuricemia]

¹Institute of Rheumatology, Tokyo Women's Medical College.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|December 1, 1996

Summary

Urate-lowering medications like uricosuric agents and allopurinol treat hyperuricemia. Choosing the right agent based on uric acid excretion, and starting with low doses, helps prevent gouty arthritis.

Area of Science:

Biochemistry
Pharmacology
Nephrology

Context:

Hyperuricemia management requires careful selection of urate-lowering agents.
Two main classes exist: uricosuric agents and allopurinol.
Phenotyping patients based on urate excretion is crucial for effective treatment.

Purpose:

To guide the selection of urate-lowering therapy based on patient phenotype.
To outline strategies for preventing complications associated with hyperuricemia treatment.

Summary:

Uricosuric agents are recommended for urate underexcretion, while allopurinol is for overproduction.
The urinary uric acid/creatinine ratio aids in determining the appropriate treatment strategy.
Initiating therapy with minimal doses and maintaining serum uric acid levels between 5.0-6.4 mg/dl minimizes gouty arthritis risk.

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Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

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Published on: October 3, 2020

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Published on: November 22, 2024

Impact:

Optimized treatment selection for hyperuricemia patients.
Reduced incidence of urinary urate stones and potential liver damage.
Decreased risk of gouty arthritis during initial treatment phases.