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The microscopic pathology of Peyronie's disease
1Department of Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, D. C. 20306-6000, USA.
Purpose:
All cases of Peyronie's disease in the files were reviewed to determine the chief microscopic findings and also to note the anatomical site of the disease process.
Materials And Methods:
The microscopic findings in 19 cases were evaluated using hematoxylin and eosin sections, and Masson trichrome was frequently used to highlight alterations of collagen structure. Movat elastic stain and fibrinogen immunostain for fibrin were used in some cases.
Results:
A perivascular lymphocytic infiltrate was found in 6 of the 19 cases, located either within the tunica albuginea or on either side of it. A linear band of ossification was found in the tunica in 5 cases. Disorganization of the collagen of the tunica was present in all cases, usually associated with a slight increase in cellularity. In 3 of 10 cases fibrin was demonstrated in the affected area of the tunica.
Conclusions:
Peyronie's disease is characterized by an alteration in the appearance and cellularity of the collagen that comprises the tunica albuginea. Ossification in the middle or inner aspect of the tunica may occur, and a perivascular lymphocytic infiltrate may or may not be present within the tunica or on either side of it.
Insights
Peyronie's disease microscopically shows collagen changes in the tunica albuginea. Ossification and lymphocytic infiltrates may also be present in affected tissues.
Area of Science:
- Urology
- Pathology
Background:
- Peyronie's disease is a connective tissue disorder affecting the tunica albuginea.
- Understanding its microscopic pathology is crucial for diagnosis and management.
Purpose of the Study:
- To determine the chief microscopic findings in Peyronie's disease.
- To identify the anatomical site of the disease process within the tunica albuginea.
Main Methods:
- Review of 19 Peyronie's disease cases.
- Microscopic evaluation using hematoxylin and eosin, Masson trichrome, Movat elastic stain, and fibrinogen immunostain.
Main Results:
- All cases exhibited collagen disorganization in the tunica albuginea, often with increased cellularity.
- Perivascular lymphocytic infiltrate observed in 6 cases.
- Ossification found in the tunica in 5 cases; fibrin detected in 3 cases.
Conclusions:
- Peyronie's disease is defined by altered collagen appearance and cellularity of the tunica albuginea.
- Ossification and lymphocytic infiltrates are potential microscopic findings.