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Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation
T Dijkhuizen1, W M Molenaar, H J Hoekstra
1Department of Medical Genetics, Groningen University, The Netherlands.
Abstract:
The cytogenetic analysis of a patient with a myxoid liposarcoma exhibiting cartilaginous differentiation is presented. A complex translocation involving chromosome 12, 16, and 19 was found, instead of the t(12;16), specific for myxoid liposarcoma. The involvement of 19q13 in a tumor with cartilaginous differentiation, and the assignment of TGF beta 1 to 19q13.1-13.2, which appears to play a role in the formation of bone and cartilage, suggest a possible relation between both.
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