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Vitrectomy and systemic fluconazole for treatment of endogenous fungal endophthalmitis
1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101, USA.
Background And Objective:
To investigate the efficacy of pars plana vitrectomy and oral fluconazole without injection of intravitreal antimycotic agents in the treatment of vitritis resulting from Candida endophthalmitis.
Patients And Methods:
Six eyes of five patients with suspected Candida endophthalmitis were treated with pars plana vitrectomy and systemic fluconazole for at least 3 weeks. Patients were observed postoperatively for at least 4 months.
Results:
Clinical signs of infection cleared and visual acuity improved postoperatively in all six cases. One recurrent case was attributed to a retained indwelling venous catheter.
Conclusions:
Treatment of advanced endogenous Candida endophthalmitis with vitrectomy and systemic fluconazole offers an effective alternative to management with intravitreal amphotericin B in selected cases.