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Related Experiment Videos

Cerebral palsy and multiple births

P O Pharoah1, T Cooke

  • 1Department of Public Health, University of Liverpool.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|November 1, 1996
PubMed
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Babies born from multiple pregnancies have a higher risk of cerebral palsy. This increased risk is seen even in normal birthweight infants, not just those with low birthweight.

Area of Science:

  • Perinatology
  • Neurology
  • Pediatrics

Background:

  • Cerebral palsy (CP) is a leading cause of childhood disability.
  • Multiple gestations are associated with increased perinatal risks.

Purpose of the Study:

  • To investigate the birthweight-specific prevalence of cerebral palsy in singleton versus multiple births.
  • To identify risk factors contributing to higher CP rates in multiple births.

Main Methods:

  • Retrospective cohort study using registered births in Merseyside and Cheshire (1982-1989).
  • Ascertainment of cerebral palsy cases in singleton, twin, and triplet births.
  • Analysis of CP prevalence stratified by birthweight categories (<2500g and >=2500g).

Main Results:

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  • Crude CP prevalence was 2.3/1000 for singletons, 12.6/1000 for twins, and 44.8/1000 for triplets.
  • Birthweight-specific prevalence of CP did not differ significantly between singleton and multiple births for low birthweight infants (<2500g).
  • Significantly higher CP risk was observed in multiple births compared to singletons among infants with normal birthweight (>=2500g).

Conclusions:

  • Infants from multiple pregnancies face an elevated risk of cerebral palsy.
  • An increased risk of cerebral palsy exists in twin pregnancies where a co-twin has demised in utero.