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A method for detecting 8-methoxypsoralen in the ocular lens
Science (New York, N.Y.)
|September 23, 1977
Summary
8-methoxypsoralen used for psoriasis treatment may be hazardous to the eye. This photosensitizing drug accumulates in the ocular lens, potentially enhancing ultraviolet light damage.
Area of Science:
- Ophthalmology
- Photochemistry
- Pharmacology
Background:
- Psoriasis treatment with 8-methoxypsoralen carries potential risks.
- Photosensitizing agents can pose hazards if they reach sensitive tissues like the ocular lens.
Purpose of the Study:
- To investigate the potential ocular toxicity of 8-methoxypsoralen.
- To quantify 8-methoxypsoralen concentration in the ocular lens after administration.
Main Methods:
- Intraperitoneal injection of 8-methoxypsoralen in rats.
- Analysis of 8-methoxypsoralen concentration using phosphorescence spectroscopy of intact rat lenses.
Main Results:
- 8-methoxypsoralen was detected in rat ocular lenses at concentrations of approximately 10(-5)M.
- Evidence suggests 8-methoxypsoralen acts as a photosensitizer within the lens.
Conclusions:
- 8-methoxypsoralen can accumulate in the ocular lens.
- The presence of 8-methoxypsoralen may increase susceptibility to ultraviolet-induced lens damage, posing a risk to vision.