[In vitro study of the sensitizing activity of an antirabies immunoglobulin and its fractions]

The dynamics of the blood in guinea pigs sensitized with heterogenous antirabic immunoglobulin was studied. The damage of neutrophils in the blood was found to be an index which allowed to detect changed sensitivity to heterogenous protein already at an early period (on day 6) after immunization, whereas the indirect mast cell degranulation test detected it only at a later period (on day 21). The above methods revealed that beta 1 and beta 2 globulin fractions possessed high sensitizing activity.