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Amifostine (Ethyol): dosing, administration and patient management guidelines
1Cleveland Clinic Foundation, Department of Hematology/Oncology, Cleveland Clinic Cancer Center, Ohio 44195-5237, USA.
Summary
Amifostine (WR-2721) offers cytoprotection against chemotherapy toxicity. Recommended at 910 mg/m2, it shows moderate side effects like hypotension and nausea but is simple to administer with chemotherapy.
Area of Science:
- Oncology
- Pharmacology
Background:
- Chemotherapy often causes significant toxicity to normal cells.
- Amifostine (WR-2721) is an emerging cytoprotective agent.
- Effective strategies are needed to mitigate chemotherapy side effects.