Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antigenic composition of adenovirus hexons]

L Döhner, U Dieckmann

    Acta Biologica Et Medica Germanica
    |January 1, 1978
    PubMed
    Summary

    Researchers quantified adenovirus hexon components using antibody fragments. Findings reveal hexons have at least 20 determinants, with half group-specific and half type-specific, aiding in viral classification.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Can spatial self-organization inhibit evolutionary adaptation?

    Journal of the Royal Society, Interface·2025
    Same author

    Decreased body mass index is associated with impaired survival in lung cancer patients with brain metastases: A retrospective analysis of 624 patients.

    European journal of cancer care·2017
    Same author

    Fish length exclusively determines sexual maturation in the European whitefish Coregonus lavaretus species complex.

    Journal of fish biology·2014
    Same author

    A generalized functional response for predators that switch between multiple prey species.

    Journal of theoretical biology·2013
    Same author

    Hybridization and speciation.

    Journal of evolutionary biology·2013
    Same author

    A systematic overview of harvesting-induced maturation evolution in predator-prey systems with three different life-history tradeoffs.

    Bulletin of mathematical biology·2012

    Area of Science:

    • Virology
    • Immunochemistry
    • Structural Biology

    Context:

    • Adenoviruses are significant human pathogens.
    • Hexons are major structural proteins of adenoviruses.
    • Understanding hexon structure is crucial for vaccine development and antiviral strategies.

    Purpose:

    • To quantitatively analyze the group-specific and type-specific determinants of adenovirus hexons.
    • To determine the number and distribution of antigenic sites on adenovirus type 2 and 5 hexons.

    Summary:

    • Quantitative analysis of adenovirus type 2 and 5 hexons using FITC-conjugated Fab-fragments of type-specific antibodies.
    • Sedimentation analysis revealed at least 20 determinants per hexon.
    • These determinants are equally divided into group-specific and type-specific components.
    • Carbodiimide sensitivity indicates distinct chemical properties within type 2 hexon components.

    Impact:

    • Provides a detailed molecular understanding of adenovirus hexon antigenicity.
    • Facilitates the development of more precise diagnostic tools for adenovirus infections.
    • Informs the design of targeted antiviral therapies and subunit vaccines.

    Related Experiment Videos