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Related Experiment Video

Updated: Jan 19, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Gastroprotective effect of ranitidine bismuth citrate is associated with increased mucus bismuth concentration in

S Tanaka¹, P H Guth, G Paulsen

¹Medical Service, West Los Angeles VA Medical Center, CA 90073, USA.

|August 1, 1996

Summary

Ranitidine bismuth citrate (GG311) protects the gastric mucosa from NSAID-induced injury by increasing bismuth concentration in gastric mucus. This mechanism may reduce proton permeability, safeguarding the stomach lining.

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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

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Published on: November 9, 2016

Inhaled Medications

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Inhaled Medications: Bronchodilators and Corticosteroids

Inhaled Medications: Bronchodilators and Corticosteroids

Area of Science:

Gastroenterology
Pharmacology

Background:

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause gastric mucosal injury.
Antisecretory and bismuth compounds offer protection against NSAID-induced gastric damage.

Purpose of the Study:

To elucidate the gastroprotective mechanism of ranitidine bismuth citrate (GG311) in a rat model.
Investigate how GG311 mitigates indomethacin-induced gastric injury.

Main Methods:

Utilized an indomethacin-induced rat gastric injury model.
Employed in vivo microscopy to simultaneously measure acid output, surface cell intracellular pH (pHi), mucus gel thickness, and mucosal blood flow.

Main Results:

GG311 demonstrated dose-dependent protection against indomethacin-induced gastric injury.
Indomethacin reduced mucus thickness and impaired pHi, while GG311 improved these parameters in its presence.
Gastric mucus bismuth concentrations were significantly elevated following GG311 administration after indomethacin pretreatment.

Conclusions:

The gastroprotective effect of GG311 is linked to sustained high bismuth concentrations within the gastric mucus.
This elevated bismuth may impede proton permeation, thereby preventing NSAID-induced gastric damage.