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Updated: Apr 28, 2026
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
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Mesenteric vasculitis associated with Sézary syndrome
R D Ellis1, C H Smith, J R Goodlad
1Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London.
Gut
|August 1, 1996
Summary
Sézary syndrome can cause mesenteric vasculitis, leading to small bowel strictures and obstruction. This case highlights the link between this rare condition and gastrointestinal complications.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Sézary syndrome is a rare T-cell lymphoproliferative disorder.
- Gastrointestinal manifestations are uncommon but can be severe.
Observation:
- A 71-year-old female with Sézary syndrome presented with chronic diarrhea and abdominal pain.
- Imaging revealed two mid-ileal strictures, indicating subacute small bowel obstruction.
Findings:
- Surgical intervention included resection of a 15 cm ileal stricture and stricturoplasty of a 10 cm stricture.
- Histopathology confirmed mesenteric vasculitis with secondary ischemic changes as the cause of the strictures.
Implications:
- This case suggests a potential association between Sézary syndrome and mesenteric vasculitis causing small bowel strictures.
- Early recognition and management of gastrointestinal complications are crucial in patients with Sézary syndrome.
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