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Age-related ocular blood flow changes

G Ravalico1, G Toffoli, G Pastori

  • 1Istituto di Clinica Oculistica, Università di Trieste, Ospedale Maggiore, Italy.

Investigative Ophthalmology & Visual Science
|December 1, 1996
PubMed
Summary
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Pulsatile ocular blood flow (POBF) significantly decreases with age, particularly after age 50 and when intraocular pressure (IOP) increases. This age-related decline in POBF is crucial for understanding eye disease hemodynamics.

Area of Science:

  • Ophthalmology
  • Physiology
  • Biomedical Engineering

Background:

  • Pulsatile ocular blood flow (POBF) is influenced by factors like intraocular pressure (IOP), heart rate, and posture.
  • Age is a significant, yet often overlooked, factor affecting POBF.

Purpose of the Study:

  • To investigate the relationship between age and POBF in healthy individuals.
  • To quantify how POBF changes across different age groups.

Main Methods:

  • 105 healthy subjects aged 10-80 years were divided into seven decade-based groups.
  • POBF and pulse amplitude (PA) were measured in sitting, supine, and suction cup-induced IOP states.

Main Results:

  • POBF and PA showed a significant decrease with increasing age, especially in the supine position and after IOP elevation.

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  • A statistically significant correlation was found between decreased POBF and older age (P < 0.001).
  • POBF decreased significantly from sitting to supine positions, associated with increased IOP.

    • Conclusions:

    • POBF declines with advancing age, with a more pronounced decrease observed in individuals over 50.
    • Age-related POBF changes are more apparent under conditions of elevated IOP.
    • Understanding age-related POBF is essential for evaluating ocular pathologies.