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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: Jul 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Repair mechanisms in asthma

S I Rennard1

  • 1University of Nebraska Medical Center, Pulmonary and Critical Care Medicine Section, Omaha 68198-5300, USA.

The Journal of Allergy and Clinical Immunology
|December 1, 1996
PubMed
Summary

Structural changes in the airway wall, including inflammation and thickened basal lamina, are key features of asthma. These alterations likely contribute to asthma

Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Histopathology

Background:

  • Asthma is characterized by reversible airflow obstruction.
  • Histologic abnormalities, particularly inflammation, are common in asthma.
  • Structural changes in the airway wall are also regularly observed.

Purpose of the Study:

  • To explore the structural alterations in the airway wall in asthma.
  • To understand the contribution of connective tissue changes to asthma pathophysiology.
  • To identify potential cellular regulators of these structural changes.

Main Methods:

  • Histologic examination of airway tissue.
  • Analysis of basal lamina composition (interstitial collagens).
  • Assessment of mesenchymal cell populations (myofibroblasts).

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Last Updated: Jul 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

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Published on: November 4, 2010

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

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08:58

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Main Results:

  • Asthma involves a thickened basal lamina with interstitial collagen accumulation.
  • There is an increase in myofibroblasts within the airway wall.
  • These connective tissue changes are associated with asthma's physiologic abnormalities.

Conclusions:

  • Structural alterations in the airway wall are integral to asthma.
  • Connective tissue changes may influence long-term asthma outcomes.
  • Airway cells, including inflammatory and epithelial cells, may regulate these structural responses.