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Updated: Jul 26, 2026
07:10
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
Published on: August 16, 2013
Late-phase inflammation: influence on morbidity
1Brenham Clinic, TX 77833, USA.
The Journal of Allergy and Clinical Immunology
|December 1, 1996
Summary
The late-phase inflammatory response may explain the rise in allergic diseases. Controlling this response with anti-inflammatory agents, rather than just crisis intervention, is key for managing conditions like asthma.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
Background:
- Increasing prevalence of asthma and allergic diseases suggests a need to understand underlying mechanisms.
- The late-phase inflammatory response is a dynamic reaction to antigen exposure, potentially contributing to increased allergic morbidity.
Purpose of the Study:
- To evaluate the role of the late-phase inflammatory response in allergic diseases.
- To explore therapeutic strategies for managing allergic diseases by targeting the late-phase response.
Main Methods:
- Review of current understanding of late-phase inflammation.
- Analysis of the effects of corticosteroids, second-generation antihistamines, and immunotherapy on inflammatory mediators and cells.
Main Results:
- Topical corticosteroids effectively block mediator release in both early and late phases.
- Second-generation antihistamines may reduce eosinophil, neutrophil, and basophil infiltration in the late phase.
- Immunotherapy shows potential for selectively targeting inflammatory aspects of the late-phase response.
Conclusions:
- Corticosteroids, second-generation antihistamines, and immunotherapy are crucial for modifying the late-phase inflammatory response.
- These therapies likely operate through distinct mechanisms to control allergic inflammation.
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