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Related Concept Videos

Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Related Experiment Video

Updated: Jul 12, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

[Chronobiological approach of aging]

Y Touitou1, A Bogdan, E Haus

  • 1Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Pathologie-Biologie
|June 1, 1996
PubMed
Summary

Understanding biological age involves studying how biological rhythms change with aging. Alterations in these rhythms may indicate reduced adaptability to environmental factors in older individuals.

Area of Science:

  • Gerontology and chronobiology
  • Study of biological rhythms and aging

Background:

  • Aging is a complex process with multiple contributing factors.
  • Biological rhythms and their alterations are key to understanding biological age.
  • Changes in rhythms may reflect reduced adaptability in aged individuals.

Purpose of the Study:

  • To explore the significance of biological rhythms in the context of aging.
  • To investigate how modifications in biological rhythms relate to biological age.
  • To understand the implications of altered rhythms for environmental adaptability in the elderly.

Main Methods:

  • Review and synthesis of existing research on biological rhythms and aging.
  • Analysis of how age-related changes affect circadian and other biological rhythms.

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Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
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Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

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Related Experiment Videos

Last Updated: Jul 12, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
10:58

Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

Published on: August 29, 2013

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

  • Exploration of the link between rhythm alterations and adaptive capacity.

    • Main Results:

    • Biological rhythms are crucial for assessing biological age.
    • Alterations in biological rhythms are observed in aged populations.
    • These alterations correlate with decreased adaptability to environmental changes.

    Conclusions:

    • Studying biological rhythm modifications is essential for understanding aging.
    • Quantifying the loss of adaptation capacity in aging is a significant research area.
    • The paper synthesizes current knowledge on this topic.