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The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization
M Egashira1, D Kitamura, T Watanabe
1Human Genetics, Nagasaki University School of Medicine, Japan. f0932@cc.nagasaki-u.ac.jp
Cytogenetics and Cell Genetics
|January 1, 1996
Abstract:
The human HS1 gene (HCLS1, hematopoietic cell-specific Lyn substrate 1) expressed in human hematopoietic cells encodes a major substrate of protein-tyrosine kinase, p75HS1. This intracellular protein is involved in the signal transduction pathways that initiate at the antigen receptors of both B and T lymphocytes. Fluorescence in situ hybridization using a 2.0-kb cDNA and an 8.0-kb genomic DNA clone of HCLS1 as probes revealed that the gene maps to 3q13.