Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization

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FISH for Pre-implantation Genetic Diagnosis
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FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

F Speleman1, G Van Camp, N Van Roy

  • 1Department of Medical Genetics, University Hospital, Gent, Belgium.

Cytogenetics and Cell Genetics
|January 1, 1996
PubMed

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...