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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
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Interleukin 6: a possible marker of disease activity in adult onset Still's disease
M A Scheinberg1, E Chapira, M L Fernandes
1Laboratory of Diagnostic Investigation, Immunology Division IBCC, Sao Paulo, Brazil.
Objective:
Adult onset Still's disease (AOSD) is an inflammatory disorder with elevated serum acute phase proteins. Interleukin-6 is a major contributor to the acute phase response. We therefore examined the serum levels of CRP, SAA and interleukin-6 in active and inactive AOSD.
Results:
Active patients had significantly elevated CRP, SAA, and interleukin-6 values. After steroid treatment a marked reduction was observed in all three parameters. There was a close kinetics on the fluctuations of CRP and SAA, but not on IL-6.
Conclusion:
Acute phase proteins and IL-6 are useful markers of disease activity in AOSD.
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