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Updated: Aug 16, 2026

Murine Model of CD40-activation of B cells
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Elevated in vivo expression of the costimulatory molecule B7-BB1 (CD80) on antigen presenting cells from a patient

B Kovacs1, D E Thomas, G C Tsokos

  • 1Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC 20307-5001, USA.

Clinical and Experimental Rheumatology
|November 1, 1996
PubMed

The CD28/CTLA4-B7-family plays an important role in T-cell costimulation and is crucial for IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is expressed on activated antigen presenting cells, but its expression on peripheral blood mononuclear cells is very low. Here we report a patient with untreated SLE whose peripheral blood antigen presenting cells expressed increased amounts of B7-BB1.

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