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The C-terminal Src kinase (Csk) is widely expressed, active in HT-29 cells that contain activated Src, and its
1Department of Neuro-Oncology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Cell Biology International
|November 1, 1996
Abstract:
Csk expression was examined in human glioma, breast and colon cell lines, along with murine tissues. Relative to colon and glioma cell lines, Csk expression was highest in the breast cell lines. Relative to brain tissue, expression was 100-fold higher in the heart, kidney, liver, lung and spleen. Subcellular fractionation and cellular immunostaining indicated that it was localized in the cytosolic fraction. The expression of Csk was downregulated upon chemical-induced differentiation of SW620 human colon cells by treatment with sodium butyrate. Its expression localization and activity relative to Src are discussed.