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Histochemical study on hemangiomas in childhood
1Clinic of Paediatric Surgery, University of Medicine, Plovdiv, Bulgaria.
Insights
This study analyzed enzyme activity in childhood hemangiomas, finding altered levels of specific enzymes like succinate dehydrogenase and alkaline phosphatase. These findings support classifying hemangiomas as tumors with a favorable prognosis.
Area of Science:
- Pediatric Pathology
- Biochemistry
- Oncology
Background:
- Hemangiomas are common pediatric vascular tumors.
- Understanding their cellular and enzymatic characteristics is crucial for diagnosis and prognosis.
Purpose of the Study:
- To investigate the histochemical enzyme activity in different types of childhood hemangiomas.
- To correlate enzyme activity with the nature and prognosis of these tumors.
Main Methods:
- Biopsy samples from 18 children with capillary, cavernous, and combined hemangiomas were analyzed.
- Histochemical reactions were performed for succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), cytochromoxidase, acid phosphatase, alkaline phosphatase, and paraspecific esterases.
Main Results:
- Reduced activity of succinate dehydrogenase (SDH) and cytochromoxidase was observed in endothelial cells and pericytes.
- A significant reduction in acid phosphatase activity was noted in most cases.
- Markedly increased activity of alkaline phosphatase and paraspecific esterases was detected.
Conclusions:
- The observed enzyme activity patterns suggest specific metabolic alterations in hemangioma cells.
- The findings support the classification of hemangiomas as benign tumor formations with a good prognosis.
Abstract:
The study was carried out on a material obtained by a biopsy from 18 children having different types of hemangiomas (capillary, cavernous and combined). Histochemical reactions were applied for the following enzymes: Succenatedehydrogenase (SDH), lactatdehydrogenase (LDH), cytochromoxidase, acid phosphatase, alkaline phosphatase and paraspecific esterases. Differently reduced activity of the succenatedehydrogenase and the cytochromoxidase in the endothelial cells and the pericytes was established. A reduced enzyme activity was observed also in a large part of the cases of acid phosphatase. The activity of the alkaline phosphatase and paraspecific esterases was greatly increased. Based on their observations the authors relate the hemangiomas to the tumour formations with a good prognosis.