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Chemotherapy in Hodgkin's disease
P K Kumari1, V G Chellam, J Madhavan
1Department of Pediatric Oncology, Regional Cancer Center, Trivandrum.
Indian Pediatrics
|July 1, 1996
Summary
Primary chemotherapy effectively treats pediatric Hodgkin
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Research
Background:
- Hodgkin's disease is a significant malignancy in children.
- Evaluating primary treatment strategies is crucial for improving outcomes.
- Chemotherapy plays a key role in managing pediatric Hodgkin's disease.
Purpose of the Study:
- To determine the effectiveness of primary chemotherapy in children diagnosed with Hodgkin's disease.
- To evaluate treatment outcomes, including remission and survival rates.
- To assess the safety profile of chemotherapy regimens in this pediatric population.
Main Methods:
- A non-randomized study conducted in a Pediatric Oncology Division.
- Twenty-nine children with clinically staged Hodgkin's disease were included.
- Twenty-one patients received combination chemotherapy (COPP or MOPP regimens).
Main Results:
- Complete remission was achieved in 19 out of 21 treated patients.
- Five-year relapse-free survival was 76%, and overall survival was 86%.
- No deaths were attributed to chemotherapy toxicity, indicating a favorable safety profile.
Conclusions:
- Combination chemotherapy is a highly effective treatment for pediatric Hodgkin's disease.
- The observed survival rates suggest significant long-term benefits.
- Primary chemotherapy demonstrates a good safety profile in children with Hodgkin's disease.