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Chemotherapy in Hodgkin's disease
P K Kumari1, V G Chellam, J Madhavan
1Department of Pediatric Oncology, Regional Cancer Center, Trivandrum.
Objective:
To assess the efficacy of primary chemotherapy in patients with clinically staged Hodgkin's disease.
Design:
Non randomized study.
Setting:
Pediatric Oncology Division of Regional Cancer Center.
Subjects:
Twenty nine children with Hodgkin's disease.
Interventions:
Chemotherapy was given to 21 patients whose parents agreed for the same. Sixteen children received COPP regimen and 5 received MOPP regimen.
Results:
Complete remission was achieved in 19 patients. The relapse free survival and overall survival in these patients were 76% and 86%, respectively at 5 years. There was no death related to chemotherapy toxicity.
Conclusion:
Combination chemotherapy is an effective modality of treatment for children with Hodgkin's disease.