The utilization of gene targeting to study mammalian neurobiology

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.

Immunity·1999

Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice.

The Journal of experimental medicine·1997

EGF in combination with depolarization or cAMP produces morphological but not physiological differentiation in PC12 cells.

Journal of neuroscience research·1997

p21ras signaling is necessary but not sufficient to mediate neurotrophin induction of calcium channels in PC12 cells.

The Journal of biological chemistry·1996

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.

Nature genetics·1995

Fibroblast growth factor-induced increases in calcium currents in the PC12 pheochromocytoma cell line are tyrosine phosphorylation dependent.

Journal of neuroscience research·1994

Radiological signature of levodopa responsiveness in Parkinson's disease: A data driven approach in a deep brain stimulation cohort.

Neurobiology of disease·2026

Alteration of cholinergic pathway in the enteric nervous system of a mouse model of Rett syndrome.

Neurobiology of disease·2026

Activity-dependent DNA methylation and demethylation: epigenetic regulators of learning and memory.

Neurobiology of disease·2026

Dysregulated phosphatidylglycerol metabolism in dorsal root ganglia contributes to pain hypersensitivity in a mouse model of Fabry disease.

Neurobiology of disease·2026

Disrupted glial metabolism and myelin vulnerability in a mouse model of glucose transporter type 1 deficiency syndrome.

Neurobiology of disease·2026

Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35.

Neurobiology of disease·2026

Longitudinal Characterization of Giant ANK2-Depleted Monkeys Suggests Neurodevelopmental-Disorder-Like Phenotypes.

Research (Washington, D.C.)·2026

Identification of the Genomic Etiology of Unexplained Congenital Problems in Pediatric Patients: First Reported Case With Coffin-Siris Syndrome and Sialuria From India.

Clinical case reports·2026

Broadening the Okur-Chung syndrome phenotype: adult-onset metabolic features and a contiguous 20p13 deletion in a Turkish multicenter cohort.

Journal of human genetics·2026

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.

Nature genetics·2026

A de novo 1.62 Mb deletion at 2q34 with nonpenetrant neurodevelopmental phenotype at 12 months.

Psychiatric genetics·2026

Case Report: novel mutations in SMARCA4 cause Coffin-Siris syndrome type 4 with autism spectrum disorder without visual impairment in one patient.

Frontiers in genetics·2026

Related Experiment Videos

The utilization of gene targeting to study mammalian neurobiology

Related Concept Videos

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.

Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice.

EGF in combination with depolarization or cAMP produces morphological but not physiological differentiation in PC12 cells.

p21ras signaling is necessary but not sufficient to mediate neurotrophin induction of calcium channels in PC12 cells.

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.

Fibroblast growth factor-induced increases in calcium currents in the PC12 pheochromocytoma cell line are tyrosine phosphorylation dependent.

Radiological signature of levodopa responsiveness in Parkinson's disease: A data driven approach in a deep brain stimulation cohort.

Alteration of cholinergic pathway in the enteric nervous system of a mouse model of Rett syndrome.

Activity-dependent DNA methylation and demethylation: epigenetic regulators of learning and memory.

Dysregulated phosphatidylglycerol metabolism in dorsal root ganglia contributes to pain hypersensitivity in a mouse model of Fabry disease.

Disrupted glial metabolism and myelin vulnerability in a mouse model of glucose transporter type 1 deficiency syndrome.

Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35.

Longitudinal Characterization of Giant ANK2-Depleted Monkeys Suggests Neurodevelopmental-Disorder-Like Phenotypes.

Identification of the Genomic Etiology of Unexplained Congenital Problems in Pediatric Patients: First Reported Case With Coffin-Siris Syndrome and Sialuria From India.

Broadening the Okur-Chung syndrome phenotype: adult-onset metabolic features and a contiguous 20p13 deletion in a Turkish multicenter cohort.

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.

A de novo 1.62 Mb deletion at 2q34 with nonpenetrant neurodevelopmental phenotype at 12 months.

Case Report: novel mutations in SMARCA4 cause Coffin-Siris syndrome type 4 with autism spectrum disorder without visual impairment in one patient.

Related Experiment Videos

The utilization of gene targeting to study mammalian neurobiology

Related Concept Videos

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