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Spironolactone therapy in hypertrichosis

F Darendeliler¹, F Bas, S Balaban

¹Istanbul Faculty of Medicine, Department of Pediatrics, Turkey.

European Journal of Endocrinology

|November 1, 1996

Summary

Spironolactone therapy reduced hair width in prepubertal girls with simple hypertrichosis. While effective short-term, hair growth tended to increase after 6-9 months, indicating a need for further research on this anti-androgen treatment.

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Area of Science:

Pediatric Endocrinology
Dermatology
Pharmacology

Background:

Simple hypertrichosis, though benign, causes cosmetic distress in children.
Abnormalities in androgen metabolism are increasingly implicated in hypertrichosis etiology.

Purpose of the Study:

To investigate the efficacy of spironolactone, an anti-androgen, in treating simple hypertrichosis in prepubertal girls.
To assess changes in hair width following spironolactone therapy.

Main Methods:

12 prepubertal girls with idiopathic hypertrichosis received oral spironolactone (25-100 mg/m²/day) for 1 year.
Hair width (total and medullary) was measured from various body areas before and during treatment.
Hormonal levels, bone age, and imaging were assessed to rule out underlying pathologies.

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Main Results:

Significant reductions in total hair width were observed in preauricular and anterior midthigh regions up to 6-9 months.
Medullary hair width decreased significantly in all measured regions within 6 months.
Both measures showed a tendency to increase after the initial 6-9 month period. No adverse effects were reported.

Conclusions:

Spironolactone demonstrates potential as a treatment for simple hypertrichosis in children.
Further research is required to establish long-term efficacy and safety of anti-androgen therapy for hypertrichosis.