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Related Experiment Videos

Where do hematopoietic stem cells come from?

F Dieterlen-Lièvre1, I Godin, L Pardanaud

  • 1Institut d'Embryologie cellulaire et moléculaire du CNRS et du Collège de France, Nogent s/Marne, France.

International Archives of Allergy and Immunology
|January 1, 1997
PubMed
Summary
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Bird and mouse studies reveal hematopoietic stem cells (HSC) originate within the embryo, not the yolk sac. Only embryonic HSCs possess lymphoid potential, impacting blood system development.

Area of Science:

  • Developmental biology
  • Hematopoiesis
  • Stem cell research

Background:

  • The origin of hematopoietic stem cells (HSC) is crucial for understanding blood system development.
  • Previous research suggested potential extraembryonic origins for early HSCs.

Purpose of the Study:

  • To determine the intraembryonic origin of avian hematopoietic stem cells (HSC).
  • To investigate the ontogeny of the mouse hematopoietic system and identify distinct HSC generations.
  • To analyze the developmental relationships between endothelial and hematopoietic cells.

Main Methods:

  • Interspecific transplantation of quail embryos onto chick yolk sacs.
  • Establishment of avian and murine cell culture systems.
  • Interspecific transplantation in avian models to distinguish endothelial lineages.

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Main Results:

  • Evidence confirms intraembryonic origin of HSCs colonizing blood-forming rudiments in birds.
  • Mouse hematopoiesis involves at least two HSC generations: yolk sac-derived and embryo-derived.
  • Only embryo-derived HSCs exhibit lymphoid potential.
  • Avian model reveals two distinct endothelial lineages: a purely endothelial dorsal lineage and a ventral lineage associated with hematopoietic cell production.

Conclusions:

  • Hematopoietic stem cells (HSC) in birds are of intraembryonic origin.
  • Mammalian hematopoiesis involves distinct embryonic and extraembryonic HSC populations with differing potentials.
  • Endothelial and hematopoietic cell development are linked, with specific lineages playing distinct roles.