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Human papillomavirus in normal cervical smears from Cape Town
J E Ramesar1, C M Dehaeck, R Soeters
1Department of Medical Microbiology, University of Cape Town.
Summary
Human papillomavirus (HPV) DNA was detected in 13% of South African women with normal cervical cytology. HPV types found were similar globally, with high-risk HPV present in 9% of participants.
Area of Science:
- Gynecology
- Virology
- Public Health
Background:
- Cervical cancer is a significant health concern globally.
- Human papillomavirus (HPV) is the primary cause of cervical cancer.
- Understanding HPV prevalence in diverse populations is crucial for prevention strategies.
Purpose of the Study:
- To determine the prevalence of HPV types in South African women with normal cervical cytology.
- To compare HPV findings in this population with global data.
Main Methods:
- Cervical smears were collected from 262 women aged 19-85 in the Cape Town metropolitan area.
- HPV DNA prevalence and types were analyzed in 192 women with normal cervical cytology using Southern blot hybridization.
Main Results:
- HPV DNA was detected in 13% (25/192) of women with normal cytology.
- High-risk HPV types, associated with cervical lesions, were found in 9% (17/192) of women.
- HPV prevalence was higher in younger women (16% in ages 20-39) compared to older women (6% in ages >39).
Conclusions:
- 13% of women with normal cervical cytology in Cape Town were positive for HPV.
- The HPV types identified in this South African cohort were comparable to those found worldwide.