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How harmless is FFA enhancement?

C Tesserommatis1, C Tsopanakis, G Symeonoglou

  • 1Department of Pharmacology, Athens University Medical School, Greece.

European Journal of Drug Metabolism and Pharmacokinetics
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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Standard heparin and low molecular weight heparin (LMWH) increase serum lipids like free fatty acids and HDL-C long after administration. These heparin effects on lipids and digoxin levels warrant further investigation.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Hematology

Background:

  • Standard heparin and low molecular weight heparin (LMWH) elevate serum lipid levels.
  • Diets high in saturated fatty acids may increase susceptibility to thrombosis.
  • The precise mechanism linking serum fatty acids to thrombosis is unclear, potentially involving platelet response modifications.

Purpose of the Study:

  • To investigate the duration of action of heparin and its fractions on serum lipid levels.
  • To examine the impact of heparin administration on serum concentrations of digoxin, a drug with a narrow therapeutic index.

Main Methods:

  • Administration of heparin and its fractions to subjects.
  • Monitoring of serum lipid profiles, including free fatty acids (FFA), triglycerides (TG), HDL-C, and total cholesterol.

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  • Measurement of serum digoxin concentrations under various conditions (heparin administration, swimming stress, lipid diet).

    • Main Results:

    • After 2 days of administration, heparin and its fractions increased serum FFA, TG, and HDL-C.
    • Seven days post-administration, FFA and HDL-C remained elevated, while TG levels decreased.
    • Serum total cholesterol levels were unaffected.
    • Digoxin levels showed non-significant increases after heparin and swimming stress, but a lipid diet significantly increased digoxin concentration.

    Conclusions:

    • Heparin and LMWH induce prolonged elevations in serum FFA and HDL-C.
    • The long-term effects of heparin on lipid metabolism require further study.
    • Dietary lipids can influence digoxin serum concentrations, highlighting potential drug-food interactions.