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Volume-activated Cl- channels

B Nilius1, J Eggermont, T Voets

  • 1KU Leuven, Laboratorium voor Fysiologie, Belgium. bernd.nilius@med.kuleuven.ac.be

General Pharmacology
|October 1, 1996
PubMed
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Volume-activated chloride current (ICl,vol) is crucial for cell volume regulation, pH balance, and membrane potential in mammalian cells. This review explores its biophysical properties, functional roles, and potential molecular candidates.

Area of Science:

  • Cellular Physiology
  • Ion Channel Biology

Background:

  • Cell swelling activates a chloride current (ICl,vol) in most mammalian cells.
  • This current is vital for cell volume homeostasis, pH regulation, and membrane potential control.
  • ICl,vol may also influence cell proliferation and differentiation.

Purpose of the Study:

  • To review the biophysical characteristics of volume-activated chloride current.
  • To explore the functional roles of ICl,vol in cellular processes.
  • To discuss potential molecular candidates for the volume-activated chloride channel.

Main Methods:

  • Literature review of biophysical, pharmacological, and molecular studies on ICl,vol.
  • Analysis of channel properties including rectification, ion selectivity, and conductance.

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  • Discussion of identified molecular candidates.

    • Main Results:

    • Volume-activated chloride channels exhibit outward rectification and iodide permeability over chloride.
    • Single channel conductances are typically small (< 5 pS) or medium (~50 pS).
    • Evidence suggests a heterogeneous family of volume-activated chloride channels.

    Conclusions:

    • ICl,vol is a multifaceted current with significant roles in cellular function.
    • The channel family is diverse, with several molecular candidates proposed.
    • Further research is needed to fully elucidate the structure and function of these channels.