Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optical and FDG mapping of frequency-specific activity in auditory cortex

A Hess1, H Scheich

  • 1Federal Institute for Neurobiology (INF), Brenneckstrasse, Magdeburg, Germany.

Neuroreport
|November 4, 1996
PubMed
Summary

Optical recording of intrinsic signals (ORIS) revealed asymmetric activity propagation in the auditory cortex of gerbils. This suggests subthreshold mechanisms for integrating complex sound frequencies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis.

European heart journal. Cardiovascular Imaging·2023
Same author

Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines.

Chemistry (Weinheim an der Bergstrasse, Germany)·2021
Same author

Phase I clinical trial of an antithrombotic drug protocol combining apixaban and clopidogrel in dogs.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021
Same author

Prediction of response to Certolizumab-Pegol in rheumatoid arthritis (PreCePRA) by functional MRI of the brain - Study protocol for a randomized double-blind controlled study.

Contemporary clinical trials communications·2021
Same author

Molecular imaging in nuclear cardiology: Pathways to individual precision medicine.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2020
Same author

Identifying Environmental Risk Factors and Mapping the Distribution of West Nile Virus in an Endemic Region of North America.

GeoHealth·2020

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Sensory Processing

Background:

  • The primary auditory cortex (AE) processes complex auditory information.
  • Understanding spatio-temporal activity patterns is crucial for deciphering neural processing.
  • Previous studies have mapped tonotopic organization but less is known about dynamic activity propagation.

Purpose of the Study:

  • To analyze frequency- and intensity-dependent spatio-temporal activity in the primary auditory cortex (AE).
  • To investigate the propagation patterns of neural activity using optical recording of intrinsic signals (ORIS).
  • To explore potential mechanisms underlying the integration of different sound frequencies.

Main Methods:

  • Utilized optical recording of intrinsic signals (ORIS) in awake Mongolian gerbils.

Related Experiment Videos

  • Employed tone stimulation to analyze auditory cortex responses.
  • Correlated ORIS findings with fluoro-2-deoxyglucose (FDG) imaging for metabolic activity mapping.

    • Main Results:

    • Observed two-dimensional and asymmetric propagation of ORIS activity.
    • Activity propagated ventrally to dorsally along isofrequency contours across all frequencies.
    • Low-frequency stimulation showed propagation across the tonotopic gradient, while high-frequency representations remained tonotopic.
    • Tonotopic asymmetries were intensity-independent.
    • FDG imaging showed tonotopically confined metabolic activity.

    Conclusions:

    • Asymmetric tonotopic propagation of ORIS activity suggests subthreshold directional interactions within the cortical network.
    • These interactions may facilitate the integration of low- and high-frequency components of complex sounds.
    • Findings provide insights into the neural basis of complex sound processing in the auditory cortex.