Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methodological considerations in neurobehavioral teratology

L P Spear1, S E File

  • 1Department of Psychology, Binghamton University, SUNY 13902-6000, USA.

Pharmacology, Biochemistry, and Behavior
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress, κ manipulations, and aversive effects of ethanol in adolescent and adult male rats.

Neuroscience·2013
Same author

Flumazenil-precipitated panic and dysphoria in patients dependent on benzodiazepines: a possible aid to abstinence.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Flumazenil-precipitated panic and dysphoria in patients dependent on benzodiazepines: a possible aid to abstinence--authors' response.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Alcohol consumption and lifestyle in medical students.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Pharmacology of human memory and cognition: illustrations from the effects of benzodiazepines and cholinergic drugs.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Is lorazepam-induced amnesia specific to the type of memory or to the task used to assess it?

Journal of psychopharmacology (Oxford, England)·2012
Same journal

Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

Pharmacology, biochemistry, and behavior·2026
Same journal

Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

Pharmacology, biochemistry, and behavior·2026
Same journal

Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

Pharmacology, biochemistry, and behavior·2026
Same journal

Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

Pharmacology, biochemistry, and behavior·2026
Same journal

Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

Pharmacology, biochemistry, and behavior·2026
Same journal

Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

Pharmacology, biochemistry, and behavior·2026
See all related articles

Reliable animal studies are crucial for understanding drug effects on neurodevelopment. Methodological rigor in neurobehavioral teratology ensures accurate prediction of developmental outcomes and informs therapeutic strategies.

Area of Science:

  • Neurobehavioral teratology
  • Developmental neurobiology
  • Pharmacology

Background:

  • Neurobehavioral teratology is expanding due to advances in neurobiology and pharmacology.
  • Animal studies provide clinically relevant data for drug exposure consequences and therapeutic development.

Purpose of the Study:

  • To highlight the importance of methodological rigor in animal studies for neurobehavioral teratology.
  • To guide researchers in designing reliable and sensitive studies on early drug exposure.

Main Methods:

  • Emphasizing appropriate selection of drug administration parameters (route, dose, timing).
  • Addressing the confounding factor of litter effects by suggesting analytical approaches.
  • Discussing the timing and conditions of behavioral testing (baseline and challenges).

Related Experiment Videos

Main Results:

  • Methodological choices significantly impact the reliability and sensitivity of animal study findings.
  • Proper control for litter effects is essential for valid results.
  • Testing under various conditions, including challenges, provides a comprehensive assessment.

Conclusions:

  • Adherence to rigorous methodological standards is critical for advancing neurobehavioral teratology.
  • Improved study designs will enhance the predictive value of animal models for human developmental outcomes.
  • Future research should prioritize methodological soundness to avoid limitations of earlier studies.