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[Chorionic villus sampling in multiple pregnancies]

Z Appelman1, D Rabinerson, B Kaplan

  • 1Dept. of Obstetrics and Gynecology, Kaplan Hospital, Rehovot.

Harefuah
|November 1, 1996
PubMed
Summary
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Prenatal genetic diagnosis using chorionic villus sampling is safe and effective for multiple pregnancies. This method accurately identified genetic abnormalities in twin and triplet pregnancies without increasing fetal loss.

Area of Science:

  • Obstetrics and Gynecology
  • Medical Genetics
  • Fetal Medicine

Context:

  • Multiple pregnancies, including twins and triplets, have a higher risk of genetic abnormalities.
  • Prenatal diagnosis is crucial for managing these risks.
  • Chorionic villus sampling (CVS) and amniocentesis are established prenatal diagnostic methods.

Purpose:

  • To evaluate the safety and efficacy of chorionic villus sampling (CVS) in multiple pregnancies.
  • To assess the accuracy of CVS in identifying genetic abnormalities in fetuses from twin and triplet gestations.
  • To report the outcomes of CVS in a series of multiple pregnancies.

Summary:

  • This study analyzed the results of chorionic villus sampling (CVS) in one twin and three triplet pregnancies.

Related Experiment Videos

  • CVS was performed as part of the routine ultrasound service between 1989 and 1995.
  • All cases of genetic abnormalities in the multiple pregnancies were successfully identified by CVS, with no associated fetal loss.

    • Impact:

    • Chorionic villus sampling (CVS) is confirmed as a safe and effective prenatal diagnostic tool for multiple pregnancies.
    • The findings support the recommendation for prenatal genetic diagnosis in high-risk multiple gestations.
    • This study contributes to the existing literature on the successful application of CVS in twin and triplet pregnancies.