Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bayesian forecasting of plasma vancomycin concentration using time-dependent pharmacokinetics]

T Nakamura1, N Wakaki, Y Kimura

  • 1Department of Hospital Pharmacy, Fukui Medical School, Japan.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|November 1, 1996
PubMed
Summary

A novel Bayesian forecasting method improves vancomycin (VCM) level predictions by accounting for time-dependent clearance changes. This new approach offers more precise and less biased VCM concentration predictions compared to standard methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats.

Kidney international·2006
Same author

Interindividual variation in the ratio between plasma morphine and its metabolites in cancer patients.

International journal of clinical pharmacology research·2004
Same author

Inactivation of srtA gene of Streptococcus mutans inhibits dextran-dependent aggregation by glucan-binding protein C.

Oral microbiology and immunology·2003
Same author

The sortase of Streptococcus mutans mediates cell wall anchoring of a surface protein antigen.

Oral microbiology and immunology·2003
Same author

Physiology of diapause and cold hardiness in the overwintering pupae of the fall webworm Hyphantria cunea (Lepidoptera: Arctiidae) in Japan.

Journal of insect physiology·2003
Same author

Beneficial effect of antibody removal and enhanced immuno suppression in flow cytometry cross match-positive and ABO-incompatible renal transplantation.

Transplantation proceedings·2002

Area of Science:

  • Pharmacokinetics and Pharmacodynamics
  • Computational Biology
  • Clinical Pharmacy

Context:

  • Accurate prediction of vancomycin (VCM) serum concentrations is crucial for effective treatment and minimizing toxicity.
  • Traditional pharmacokinetic models may not fully capture the dynamic changes in drug clearance during treatment.
  • Bayesian forecasting offers a flexible approach to personalize drug dosage adjustments.

Purpose:

  • To develop and evaluate a new modified Bayesian forecasting method for predicting vancomycin (VCM) pharmacokinetics.
  • To compare the precision and bias of the new method against the ordinary Bayesian forecasting method.
  • To assess the impact of time-dependent changes in VCM clearance on prediction accuracy.

Summary:

  • A modified Bayesian forecasting method incorporating time-dependent clearance was developed for vancomycin (VCM).

Related Experiment Videos

  • Serum VCM concentrations were predicted using both the new and ordinary methods in four patients.
  • The new method demonstrated superior precision (lower ME, MAE, RMSE) and reduced bias in VCM concentration predictions.
  • Observed time-dependent decreases in VCM clearance in all patients underscored the limitations of the ordinary method.

    • Impact:

    • The developed method provides a more accurate tool for predicting VCM levels, especially when clearance changes over time.
    • Improved VCM prediction can lead to optimized dosing regimens, enhancing therapeutic efficacy.
    • This advancement has the potential to improve patient outcomes by ensuring safer and more effective vancomycin therapy.