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Related Experiment Videos

Reversible bone marrow depression by high-dose piperacillin/tazobactam

G Ruiz-Irastorza1, G Barreiro, C Aguirre

  • 1Service of Internal Medicine, Hospital de Cruces, Bizkaia, Basque Country, Spain.

British Journal of Haematology
|December 1, 1996
PubMed
Summary

This case study reports reversible pancytopenia in an underweight patient treated with piperacillin/tazobactam. It highlights the importance of dose adjustment and monitoring for beta-lactam antibiotic bone marrow toxicity.

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Area of Science:

  • Pharmacology
  • Hematology
  • Internal Medicine

Background:

  • Bone marrow toxicity, including neutropenia, is an uncommon side effect of beta-lactam antibiotics, often linked to cumulative dosage.
  • While piperacillin has been associated with marrow depression, no such cases have been reported for piperacillin/tazobactam.