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Cloning and functional characterization of a rat urea transporter: expression in the brain
C Couriaud1, P Ripoche, G Rousselet
1Service de Biologie Cellulaire, CEA/Saclay, Gif-sur-Yvette, France.
Biochimica Et Biophysica Acta
|December 11, 1996
Abstract:
A cDNA coding for a rat urea transporter is described. The 1242 bp open reading frame codes for a 414 amino acids protein with 77.0% and 60.7% identity with the human UT11 and the rat UT2, respectively. When expressed in Xenopus oocytes, the protein induces a 10-fold rise in urea permeability, inhibited by mercurial reagents and phloretin. The rUT11 mRNA is massively expressed in the brain.