[Modeling the cell cycle of complex populations]

A model of cell cycle kinetics of complex populations is developed, by using systems of difference equations, and simulated on the computer. This model provides theoretical curves of labeled mitoses (PLM) percentage, labeling index and grain count histograms for different time intervals after 3H-thymidine administration. The PLM curve corresponding to a mixed population is a weighed sum of PLMs for populations, comprising the mixture, the weights being determined by parameters of populations. The model appeared to give a good agreement with the PLM curves obtained elsewhere.