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Related Experiment Videos

Particle uptake and translocation across epithelial membranes

N W Thomas1, P G Jenkins, K A Howard

  • 1Department of Pharmaceutical Sciences, University of Nottingham, UK.

Journal of Anatomy
|December 1, 1996
PubMed
Summary

Biodegradable microparticles show promise for oral drug and vaccine delivery by protecting molecules from digestion and enhancing absorption. Further research explores lipid vehicles and M cell transport to improve oral delivery systems.

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Area of Science:

  • Biotechnology
  • Pharmaceutics
  • Immunology

Background:

  • Oral drug and vaccine delivery offers advantages like mucosal immune response induction.
  • Challenges include gastrointestinal degradation, poor absorption of macromolecules, and weak immune responses to soluble antigens.
  • Biodegradable microparticles are investigated to protect labile molecules and enhance absorption.

Purpose of the Study:

  • To review particle uptake across the gastrointestinal tract.
  • To determine if biodegradable poly(DL lactide-coglycolide) microparticles can elicit a humoral immune response.
  • To explore lipid delivery vehicles and M cell transport for enhanced microparticle uptake.

Main Methods:

  • Incorporation of molecules into biodegradable microparticles.

Related Experiment Videos

  • Review of particle uptake mechanisms across the gastrointestinal tract.
  • Studies on antigen association with poly(DL lactide-coglycolide) microparticles and evaluation of humoral response.
  • Investigation of lipid delivery vehicles and microsphere transport across M cells.

    • Main Results:

    • Biodegradable microparticles can reduce the effect of gut secretions and enable absorption of bioactive agents.
    • Particle uptake across the gut wall is a biological phenomenon, though mechanisms and routes are not fully established.
    • Studies indicate potential for eliciting a humoral response with antigen-associated microparticles.
    • Lipid delivery vehicles may enhance microparticle uptake and selective transport across M cells.

    Conclusions:

    • Biodegradable microparticles represent a viable strategy for improving oral drug and vaccine delivery.
    • Further research into uptake mechanisms and enhancement strategies like lipid vehicles is crucial.
    • Targeting M cells may improve the efficacy of oral delivery systems.