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Low power laser irradiation reduces ischemic damage in hippocampal slices in vitro
1Department of Pharmacology, Kyushu University School of Dentistry, Fukuoka, Japan.
Background And Objective:
Low power laser irradiation has been reported to reduce injury, promote regeneration, and produce analgesia. While the mechanism is unknown, one hypothesis is that light produces free radicals, which have a beneficial effect at low concentrations.
Study Design/Materials And Methods:
We have investigated the effects of low power laser irradiation on the loss of electrical excitability of hippocampal brain slices after a transient exposure to a perfusion medium lacking oxygen and containing reduced glucose concentrations. Injury in this system is known to result at least in part from free radical production.
Results:
Low power laser irradiation increased the time required for loss of excitability and increased recovery from the ischemic injury.
Conclusions:
Low power laser irradiation has acute protective effects against ischemic damage in brain slices.