[The treatment of vibration-induced disease with calcium-channel blockers]

Effectiveness was studied of two drug preparations of calcium antagonists CAs group: cordaphene (30 mg) and diltiazeme (180 mg) in patients with vibration disease (VD) due to local vibration. CAs were shown to exert peripheral vasodilating, membrane-protecting and antioxidant effects. Cordaphene appeared to have a most pronounced CAs effect. We should advise its prescription preferably in those VD patients presenting with concomitant arterial hypertension.