Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laceration of Perineum in Forceps Cases: Prevention of.

Buffalo medical and surgical journal·2023
Same author

Predicted coreceptor usage at end-stage HIV disease in tissues derived from subjects on antiretroviral therapy with an undetectable plasma viral load.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2017
Same author

Progress testing in undergraduate dental education: the Peninsula experience and future opportunities.

European journal of dental education : official journal of the Association for Dental Education in Europe·2015
Same author

Germination-associated events and the desiccation sensitivity of recalcitrant seeds - a study on three unrelated species.

Planta·2013
Same author

A randomized, double-blind, placebo-controlled trial of olsalazine for active Crohn's disease.

Inflammatory bowel diseases·2013
Same author

Association of caspase-9 and RUNX3 with inflammatory bowel disease.

Tissue antigens·2010
Same journal

USP20 promotes CD8<sup>+</sup> T cell exhaustion and impairs KRAS<sup>G12D</sup> inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer.

Gut·2026
Same journal

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease.

Gut·2026
Same journal

<i>Helicobacter pylori</i> infection, treatment and colorectal cancer risk by genetic predisposition: evidence from two randomised trials.

Gut·2026
Same journal

Correction: Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

Gut·2026
Same journal

Correction: Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.

Gut·2026
Same journal

Cancer risk in autoimmune gastritis: perspectives from a Chinese cohort.

Gut·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 17, 2013

Predicting outcome in severe ulcerative colitis

S P Travis1, J M Farrant, C Ricketts

  • 1Gastroenterology Unit, John Radcliffe Hospital, Oxford.

Gut
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Predicting colectomy in severe ulcerative colitis is crucial. Early identification of patients needing surgery can be achieved by monitoring stool frequency and C-reactive protein (CRP) levels within the first three days of intensive treatment.

More Related Videos

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Related Experiment Videos

Last Updated: Jun 23, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 17, 2013

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Inflammatory Bowel Disease Research

Background:

  • Severe ulcerative colitis (UC) management requires simple criteria to identify patients likely to fail intensive medical therapy and necessitate colectomy.
  • Predictive markers are needed to guide treatment decisions and surgical intervention in severe UC cases.

Purpose of the Study:

  • To determine if early changes in inflammatory markers and clinical variables can predict the need for colectomy in severe UC patients.
  • To evaluate the one-year outcomes of medical treatment for severe ulcerative colitis.

Main Methods:

  • A prospective study of 51 consecutive severe UC episodes (Truelove and Witts criteria) in 49 patients.
  • Monitoring of 36 clinical, laboratory, and radiographic variables, with treatment including intravenous/rectal hydrocortisone and, in some cases, cyclosporine.

Main Results:

  • Stool frequency and C-reactive protein (CRP) levels within the first five days effectively distinguished between treatment outcomes.
  • On day 3, >8 stools/day or 3-8 stools/day with CRP >45 mg/l predicted colectomy with 85% accuracy.
  • Complete responders (21/51) had a median 9-month remission, while incomplete responders (15/51) faced a 60% chance of persistent symptoms and 40% risk of colectomy.

Conclusions:

  • Patients with >8 stools/day or CRP >45 mg/l after three days of intensive treatment are likely to require colectomy.
  • The efficacy of cyclosporine in severe UC requires further definition.
  • After seven days, >3 stools/day with visible blood indicates a significant risk of long-term symptoms or colectomy.