Serum adenosine deaminase estimation in relation to BCG vaccination
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Published on: September 19, 2016
S Thora1, P Rajsekaran, B C Chhaparwal
1Department of Pediatrics, M.G.M. Medical College, Indore.
Insights
Serum adenosine deaminase (ADA) levels significantly increase after BCG vaccination in newborns, indicating a rise in cell-mediated immunity. This suggests ADA is a useful marker for immune response post-vaccination.
Area of Science:
- Immunology
- Pediatrics
- Vaccinology
Background:
- Serum adenosine deaminase (ADA) levels correlate with T lymphocyte activity and cell-mediated immunity.
- BCG vaccination is a crucial immunization for preventing tuberculosis, stimulating cell-mediated immunity.
Purpose of the Study:
- To investigate the impact of BCG vaccination on serum ADA levels in term newborns.
- To assess the utility of serum ADA as a biomarker for cell-mediated immunity following BCG vaccination.
Main Methods:
- Serum ADA levels were measured in 100 term newborns at birth and 6 weeks post-BCG vaccination.
- A follow-up was conducted with 67 of the initially enrolled subjects.
Main Results:
- The mean serum ADA level at birth was 6.69 U/litre.
- After 6 weeks of BCG vaccination, the mean serum ADA level rose significantly to 13.83 U/litre.
Conclusions:
- Serum ADA levels show a significant increase after BCG vaccination in newborns.
- Serum ADA can serve as a reliable indicator of cell-mediated immune response to BCG vaccination.
Abstract:
Serum adenosine deaminase (ADA) levels reflect activity of stimulated T lymphocytes and its levels are raised whenever cell mediated immunity is stimulated. One hundred term normal newborns were studied to evaluate effect of BCG vaccination on serum ADA levels. Serum ADA was measured at birth and 6 weeks after BCG vaccination. Only 67 subjects came for follow up after 6 weeks. The levels were 6.69 U/litre at birth and 13.83 U/litre after 6 weeks of vaccination showing a significant rise. It is concluded that serum ADA levels can be used as a measure of cell mediated immunity after BCG vaccination.
