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Serum adenosine deaminase estimation in relation to BCG vaccination
S Thora1, P Rajsekaran, B C Chhaparwal
1Department of Pediatrics, M.G.M. Medical College, Indore.
Indian Pediatrics
|October 1, 1995
Summary
Serum adenosine deaminase (ADA) levels significantly increase after BCG vaccination in newborns, indicating a rise in cell-mediated immunity. This suggests ADA is a useful marker for immune response post-vaccination.
Area of Science:
- Immunology
- Pediatrics
- Vaccinology
Background:
- Serum adenosine deaminase (ADA) levels correlate with T lymphocyte activity and cell-mediated immunity.
- BCG vaccination is a crucial immunization for preventing tuberculosis, stimulating cell-mediated immunity.
Purpose of the Study:
- To investigate the impact of BCG vaccination on serum ADA levels in term newborns.
- To assess the utility of serum ADA as a biomarker for cell-mediated immunity following BCG vaccination.
Main Methods:
- Serum ADA levels were measured in 100 term newborns at birth and 6 weeks post-BCG vaccination.
- A follow-up was conducted with 67 of the initially enrolled subjects.
Main Results:
- The mean serum ADA level at birth was 6.69 U/litre.
- After 6 weeks of BCG vaccination, the mean serum ADA level rose significantly to 13.83 U/litre.
Conclusions:
- Serum ADA levels show a significant increase after BCG vaccination in newborns.
- Serum ADA can serve as a reliable indicator of cell-mediated immune response to BCG vaccination.