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Assisted hatching in an in vitro fertilization programme

F R Parikh¹, S A Kamat, S Nadkarni

¹Department of Infertility Management and Assisted Reproduction, Jaslok Hospital and Research Centre, Bombay, India.

Journal of Reproduction and Fertility. Supplement

|January 1, 1996

Summary

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Assisted hatching using partial zona dissection significantly improves pregnancy rates for women over 38 with previous implantation failures and thick zona. This technique offers new hope for successful in vitro fertilization outcomes.

Area of Science:

Reproductive Medicine
Embryology
In Vitro Fertilization (IVF)

Background:

Poor implantation is a significant challenge in assisted reproductive technologies.
Previous cycles of failed implantation and specific embryo characteristics (thick zona) indicate a need for advanced techniques.

Purpose of the Study:

To evaluate the efficacy of assisted hatching by partial zona dissection in improving pregnancy rates.
To assess the outcomes in women with a history of failed implantation and thick zona pellucida.

Main Methods:

Assisted hatching was performed on day 3 of embryo culture using mechanical partial zona dissection.
The study included women undergoing in vitro fertilization (IVF) and micromanipulation with previous implantation failures.
Embryos with zona thickness greater than 15 microns were selected for the procedure.

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Main Results:

Pregnancy rates were significantly higher in the assisted hatching groups (50% IVF, 44% micromanipulation) compared to control groups (10% IVF, 19.2% micromanipulation).
The damage rate after hatching was low at 1.4%.
The technique showed particular benefit for women over 38 years of age.

Conclusions:

Assisted hatching by partial zona dissection is an effective method to improve pregnancy rates in selected patient groups.
This technique is beneficial for women over 38 with thick zona and a history of failed implantation.
This study reports the first pregnancy in India achieved through assisted hatching (partial zona dissection).