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[Polyarthritis associated with myelodysplastic syndromes]
I Carvajal Méndez1, J A García Vadillo, A Herranz Varela
1Servicios de Reumatología, Hospital Universitario de La Princesa, Madrid.
Revista Clinica Espanola
|August 1, 1996
Summary
Myelodysplastic syndromes (MDS) can cause chronic polyarthritis. This inflammatory joint condition often requires glucocorticoids and may precede a blood disorder diagnosis.
Area of Science:
- Rheumatology
- Hematology
- Oncology
Context:
- Rheumatic manifestations are increasingly recognized in patients with myelodysplastic syndromes (MDS).
- Understanding the prevalence and characteristics of joint inflammation in MDS is crucial for early diagnosis and management.
- This study investigates inflammatory arthritis associated with MDS within a specific institutional setting.
Purpose:
- To determine the prevalence of joint inflammatory manifestations in patients with myelodysplastic syndromes (MDS).
- To characterize the clinical features of arthritis associated with MDS.
- To assess the treatment response for arthritis in MDS patients.
Summary:
- A review of 55 patients with MDS identified three cases (5.4% prevalence) of chronic non-erosive polyarthritis.
- Arthritis was present at the time of hematological diagnosis in two patients.
- The polyarthritis showed poor response to NSAIDs, necessitating intermediate-dose glucocorticoids for control.
Impact:
- Highlights the importance of considering MDS in the differential diagnosis of late-onset polyarthritis, especially with co-existing cytopenia.
- Suggests that early recognition of articular symptoms can lead to timely MDS diagnosis.
- Indicates that intermediate-dose glucocorticoids are often required for managing MDS-associated arthritis.