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Related Experiment Videos

Systemic effects of hypernephroma

S V Cherukuri, P W Johenning, M D Ram

    Urology
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Systemic effects, not classic symptoms, often present hypernephromas (kidney cancer). Early diagnosis and follow-up care improved with evaluating these tumor-related systemic effects.

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    Area of Science:

    • Oncology
    • Nephrology

    Background:

    • Hypernephromas, also known as renal cell carcinoma, can present with varied clinical manifestations.
    • Traditional diagnostic criteria, including the classic triad, are often absent in patients.

    Purpose of the Study:

    • To investigate the systemic effects associated with hypernephromas.
    • To determine the diagnostic utility of these systemic effects in early detection and follow-up care.

    Main Methods:

    • Retrospective analysis of 30 patients diagnosed with hypernephromas.
    • Detailed examination of presenting symptoms, systemic effects, and laboratory findings.
    • Correlation of tumor removal with the remission of systemic effects.

    Main Results:

    • 23 out of 30 patients exhibited systemic effects; for 5, these were the initial diagnostic indicators.

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  • Urologic complaints were less frequent (17 patients); the classic triad was not observed in any patient.
  • Common systemic effects included weight loss (52%), pyrexia, elevated sedimentation rate (36%), anemia (25%), abnormal liver function, elevated alkaline phosphatase, hypertension, erythrocytosis, and hypercalcemia.

    • Conclusions:

    • Systemic effects are crucial indicators for hypernephroma diagnosis, often preceding urologic symptoms.
    • Evaluating systemic effects aids in early diagnosis and effective patient follow-up.
    • Tumor resection generally leads to the remission of these paraneoplastic syndromes.