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[Intermittent prophylaxis in febrile seizures with oral diazepam: study of 82 cases]
M Costa1, E A Silva, A E Silva
1Departamento de Neurologia, Universidade Estadual de Campinas, Brasil.
Abstract:
We present our results of intermittent prophylaxis with oral diazepam in febrile seizures. We treated 82 patients aged between 3 months and 5 years. They have had simple or complex febrile seizures. Recurrence occurred in 22 patients (26%), none had a long-lasting febrile convulsion. Transient side effects occurred in 21.95% of the cases. We conclude that diazepam is a safe and effective drug for prophylaxis of febrile seizures when used as soon as any sign of illness appears. We suggest, however, that the administration of the drug should be indicated if the child presents at least one consistent predictor of risk of recurrent febrile seizures.
Insights
Oral diazepam effectively prevents recurrent febrile seizures in children. This treatment is safe and recommended for children with risk factors, showing minimal side effects.
Area of Science:
- Pediatrics
- Neurology
- Pharmacology
Context:
- Febrile seizures are common in young children.
- Prophylaxis aims to prevent seizure recurrence.
- Oral diazepam is a potential treatment option.
Purpose:
- To evaluate the efficacy and safety of intermittent oral diazepam prophylaxis for febrile seizures.
- To determine the recurrence rate and side effects associated with diazepam use.
Summary:
- A study involving 82 children (3 months to 5 years) with febrile seizures investigated intermittent oral diazepam prophylaxis.
- Recurrence was observed in 26% of patients, with no long-lasting convulsions.
- Transient side effects were reported in 21.95% of cases.
Impact:
- Diazepam is a safe and effective prophylactic agent for febrile seizures.
- Intermittent diazepam administration is suggested for children with identified risk factors for recurrence.