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[Multimodal iatrogenic apathy]

R D Oliveira-Souza1, W M Figueiredo

  • 1Serviço de Clínica Médica, Hospital Universitário, Gaffrée e Guinle, Rio de Janeiro.

Arquivos De Neuro-Psiquiatria
|June 1, 1996
PubMed
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[Persistent alpha-vegetative state].

Arquivos de neuro-psiquiatria·1989
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Antidepressants can cause apathy, a condition characterized by a lack of emotional experience. This side effect necessitates prompt drug withdrawal and aids in understanding the brain

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Context:

  • Antidepressant medications are widely prescribed for mood disorders.
  • Apathy is a recognized but often misunderstood symptom.
  • Distinguishing apathy from other negative symptoms is crucial for diagnosis.

Purpose:

  • To report on five cases of apathy as an antidepressant side effect.
  • To differentiate apathy from avolition and abulia based on emotional experience.
  • To review evidence distinguishing unimodal from multimodal apathy.

Summary:

  • Apathy, defined by a near-absence of emotional experience, emerged as a side effect in five patients treated with antidepressants.
  • This symptom suggests an adverse drug effect, warranting prompt discontinuation.

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  • Pathophysiology involves amygdala-temporo polar cortex neural nets integrating sensory input with emotional tone, potentially via serotoninergic circuits.

    • Impact:

    • Highlights apathy as a potential antidepressant adverse effect.
    • Underscores the importance of distinguishing apathy for accurate diagnosis and treatment.
    • Provides insights into the neurobiological underpinnings of emotions and psychopathology.